Author

Heidi Carias Martinez

Novartis (Switzerland)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:protein structure· 1

Frequent Co-Authors

Ala M. ShaqraiD· 1 shared Celia A. SchifferiD· 1 shared Daniel N. A. BoloniD· 1 shared Dustin DovalaiD· 1 shared Julia M. FlynniD· 1 shared Neşe Kurt YılmaziD· 1 shared Sarah N. ZvornicaniniD· 1 shared Stephanie A. MoquiniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

Ala M. ShaqraORCID

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1 paper

Recent·Most cited

BiochemistrymBioPeer-reviewedApr 9, 2025

Molecular Mechanisms of Drug Resistance and Compensation in SARS-CoV-2 Main Protease: The Interplay Between E166 and L50

Sarah N. Zvornicanin, Ala M. Shaqra, Julia M. Flynn…·Celia A. Schiffer

This study investigates drug resistance mechanisms in SARS-CoV-2 Mpro caused by E166 mutations and their compensation by L50F, revealing structural and functional impacts on inhibitor binding and catalytic efficiency.

19 citationstop 1%

protein structureexperimental assay

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