Oral L-arginine cures arginase 1-dependent chronic cutaneous leishmaniasis by redirecting the T helper cell response
Baplu Rai, David Barinberg, Chunguang Liang, Andrea Debus, Manfred Rauh, Sinan Kirici, Heidi Sebald, Myriam Grotz, Tobias Gold, Meik Kunz, Aline Bözec, Jochen Mattner, Sigrid C. Roberts, Ingeborg Becker, Christian Bogdan, Ulrike Schleicher
Oral L-arginine therapy prevents and cures arginase 1-dependent chronic cutaneous leishmaniasis by restoring arginine levels and shifting the T helper cell response.
bioRxiv · Sep 23, 2025 · PreprintImmunology