Marco Colonna

This study shows TREM2 drives pro-scarring macrophage accumulation in infarcted myocardium, leading to fibrosis and reduced cardiac repair.

This study identifies an IL-34-IGF-1 axis between macrophages and KRAS-mutant lung tumor cells that promotes tumor progression and poor survival.

This study shows that a perturbed small intestinal microbiota from stunted children can induce EED-like features in offspring through inflammation and immune changes.

A CRISPRi screen identifies SON and MAP4K1 as regulators of IL-22 and IL-17 expression in innate lymphoid cells, revealing new therapeutic targets for immune-mediated diseases.

This study uses somatic mutations to track marrow-derived cell infiltration into the human brain, finding widespread microglia replenishment and a protective link between clonal hematopoiesis and Alzheimer's disease.

The paper identifies distinct transcriptional and epigenetic profiles of brain-engrafted monocyte-derived macrophages compared to microglia, showing their origin from peripheral blood and skull bone marrow.

This study tracks the fate of monocyte-derived macrophages (MDMs) after traumatic brain injury (TBI) and finds they persist in the brain for up to 8 months, maintaining a distinct transcriptomic profile and phagocytic activity.

The paper identifies TREM2-expressing macrophages as predictors of response to PD-1 blockade in HCC patients using clinical and spatial transcriptomic data.

This study identifies TREM2+ lipid-laden macrophages in alveolar TB pneumonia that support Mtb survival, contrasting with granulomas, and shows pharmacological reversal of this immunometabolic state.

The paper identifies two enhancers regulating IL-22 expression in type 3 lymphoid cells, showing distinct roles in different subsets and functions in disease models.

This study shows that eosinophils contribute to chronic cutaneous leishmaniasis by expressing a unique metabolic profile that suppresses Th1 responses.

The paper identifies RORγt-expressing dendritic cells as a distinct APC lineage conserved across tissues and species, with functions beyond promoting tolerance.

The paper introduces Incytr, a method for discovering cell signaling pathways from multi-omics data, demonstrating its application in disease contexts and showing its utility for drug discovery and understanding cell communication.

The paper examines how different microbes affect host immune and barrier responses in respiratory epithelial cultures, finding that interferon variability is not linked to microbial diversity or other innate pathways.

The paper uses multi-omics approaches to identify hyperactivated IFNG signaling in PCD, linking it to immune and stromal cell pathogenesis and suggesting IFNG as a therapeutic target.

This study compares neoantigen vaccines and immune checkpoint therapies, finding they use distinct and overlapping mechanisms, with combined use showing superior efficacy.

The paper identifies TGF-β signaling as a regulator of natural killer cell function in both pregnancy and tumor progression by analyzing immune compartment dynamics in human and mouse models.

This paper develops an inducible genetic tool to study microglial states in development and disease, revealing their plasticity and functional roles.

This study shows microglia control vessel calcification via TREM2, with ablation worsening calcification and revealing a new role in preventing ectopic calcification.