Stefan Wirtz

This study investigates nanoplastic uptake and distribution in zebrafish and mouse models, showing that the glomerular filtration barrier restricts renal nanoplastic accumulation and that gut microbiota may mediate long-term kidney stress.

This study shows that persistent STAT6 activation in keratinocytes leads to chronic AD-like skin inflammation, pruritus, and S. aureus colonization in mice.

This study shows that local albumin excess in the vagina exacerbates Candida albicans-induced inflammasome activation, contributing to hyperinflammation in vulvovaginal candidiasis.

This study shows that Prevotella intestinalis induces arthritis in resistant mice by activating intestinal immune cells and promoting Th17 differentiation through IL-6.

This study identifies IBD type-associated EGC activation signatures and reveals TNF/IFN-γ-driven necroptosis of activated enteric glia in inflammatory bowel diseases.

The paper shows that Il33-expressing cDC2s drive ILC2 expansion and eosinophilia in male mice during fungal airway inflammation, independent of ST2 and dependent on IL-4/13.

The paper compares 13 mouse models of intestinal inflammation with human IBD datasets to identify translatable pathways and introduces a web tool for analyzing these models.

This study integrates multi-omic and multimodal data from IBD patients to identify molecular, histopathological, and clinical features associated with inflammatory bowel diseases.

This study shows that eosinophils contribute to chronic cutaneous leishmaniasis by expressing a unique metabolic profile that suppresses Th1 responses.