Cell state-specific metabolic networks govern ferroptosis versus apoptosis in small cell lung cancer
Jun W. Kim, Christina M. Bebber, Yuqin Dai, Sarah Bopp, Anna Edenhofer, Albert Mao Li, Thomas N. Rösner, Lena Berning, Ming Yang, Logan B. Leak, Jenny Stroh, Bindesh Shrestha, Ali Taleb Abdallah, Dimitrios Prymidis, Hernando J. Olivos, , Julien Sage
The paper identifies metabolic differences between ASCL1-high and low SCLC cells, showing that ASCL1-high cells resist ferroptosis via BH4/BH2 antioxidants and are vulnerable to combined cysteine depletion and BH4/BH2 inhibition.
bioRxiv · Mar 31, 2026 · PreprintCancer Biology