Ming Yang

Metabolic-secretory decoupling defines a disease-intrinsic state in rheumatoid arthritis monocytes

The paper identifies a stable metabolic-secretory defect in RA monocytes across activation states using multi-omics analysis, linking reduced glycosylation to disease mechanisms.

ABA-responsive transcription factor CbNAC63 is involved in modulating biosynthesis of triterpenoid saponins in Conyza blinii

The paper identifies CbNAC63 as a transcription factor that integrates ABA and cold signals to enhance triterpenoid saponin biosynthesis in Conyza blinii.

Cell state-specific metabolic networks govern ferroptosis versus apoptosis in small cell lung cancer

The paper identifies metabolic differences between ASCL1-high and low SCLC cells, showing that ASCL1-high cells resist ferroptosis via BH4/BH2 antioxidants and are vulnerable to combined cysteine depletion and BH4/BH2 inhibition.

Dissecting Tissue Architecture and Function through Mapping of Cellular Communication Networks

The paper introduces a method to infer cell-cell communication networks from spatial transcriptome data and demonstrates its effectiveness in identifying communication hotspots and tissue architecture in a mouse brain dataset.

Multi-omic characterization of allele-specific regulatory variation in hybrid pigs

This study characterizes allele-specific regulatory variation in hybrid pigs using multi-omic data across tissues and developmental stages, identifying genes influenced by parent-of-origin and genotype effects.

Epigenetic Reprogramming of Tissue-Specific Transcription Promotes Metastasis

This study shows that epigenetic reprogramming of tissue-specific transcription in cancer cells promotes metastasis, with FOXA2 playing a key role in liver colonization by metastatic colorectal cancer cells.