Jeffrey E. Pessin

The paper identifies female-specific m6A RNA methylation changes in mouse livers under high-fat diet that correlate with post-transcriptional metabolic adaptations and protein remodeling.

This study shows TIGAR deficiency protects the heart through epigenetic regulation of Parkin, enhancing mitochondrial quality control and preventing cardiac damage.

The paper shows that gluconeogenic gene expression and activity in liver hepatocytes change spatially and temporally during feeding, fasting, and starvation states.

The paper examines mRNA, protein, and lipogenesis activity in hepatocytes during feeding and starvation, finding widespread discordance between mRNA and protein levels, especially in sex-biased genes and lipogenic pathways.

This study shows that liver-innervating vagal sensory neurons contribute to hepatic steatosis and anxiety-like behavior in mice on a high-fat diet, and their removal prevents obesity and improves metabolic outcomes.

This study shows that parasympathetic cholinergic neurons innervating the liver prevent hepatic steatosis in mice on a high-fat diet by promoting browning of white adipose tissue and altering bile acid metabolism.

This study shows that neuronal SNAP-23 is essential for hippocampal synaptic plasticity and spatial memory but not for basal glutamate receptor function.

The paper shows that carbohydrate-induced gene expression changes in mouse liver vary by strain, with C57BL/6J showing greater sensitivity to sugar intake.