Author

Hiroaki Kikuchi

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Assay:bulk RNA-seq· 3 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:database / resource· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Chin‐Rang YangiD· 3 shared Lihe CheniD· 3 shared Mark A. KnepperiD· 3 shared Chung‐Lin ChouiD· 2 shared Euijung ParkiD· 2 shared Hyun Jun JungiD· 2 shared Viswanathan Raghuram· 2 shared Adrián Rafael Murillo‐de‐OzoresiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersSystems Biology

Chin‐Rang YangORCID

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Author profile →

4 papers

Recent·Most cited

Vasopressin-Dependent β-Catenin Phosphorylation at Ser552 and Branching Structure of Mouse Collecting Duct System

Shuo‐Ming Ou, Hiroaki Kikuchi, Euijung Park, Chin‐Rang Yang, Viswanathan Raghuram, Shaza Khan, Adrián Rafael Murillo‐de‐Ozores, Lihe Chen, Chung‐Lin Chou, Mark A. Knepper

This study shows that mutating Ser552 in β-catenin in mice alters collecting duct branching without affecting differentiation, suggesting vasopressin-mediated phosphorylation at Ser552 influences CD development.

bioRxiv · Mar 13, 2025 · PreprintPhysiology

ULK1-regulated AMP sensing by AMPK and its application for the treatment of chronic kidney disease

Tomoki Yanagi, Hiroaki Kikuchi, Koh Takeuchi, Koichiro Susa, Takayasu Mori, Motoko Chiga, Kouhei Yamamoto, Asuka Furukawa, Takumi Kanazawa, Yuki Kato, Naohiro Takahashi, Takefumi Suzuki, Yutaro Mori, Benjamin C. Carter, Makiko Mori, , Eisei Sohara

This study identifies ULK1-dependent AMPK activation mechanisms and shows MK8722 improves renal function in CKD.

Kidney International · Oct 18, 2024Peer-reviewedMolecular Biology

Circadian Gene Expression in Mouse Renal Proximal Tubule

Molly A. Bingham, Kim Neijman, Chin‐Rang Yang, Angel M. Aponte, Angela Mak, Hiroaki Kikuchi, Hyun Jun Jung, Brian G. Poll, Viswanathan Raghuram, Euijung Park, Chung‐Lin Chou, Lihe Chen, Jens Leipziger, Mark A. Knepper, Margo Dona

The paper identifies circadian gene expression patterns in mouse renal proximal tubules and provides a web resource for these data.

American Journal of Physiology-Renal Physiology · Feb 2, 2023Peer-reviewedSystems Biology

Early Signaling Events in Renal Compensatory Hypertrophy Revealed by Multi-Omics

Hiroaki Kikuchi, Chun-Lin Chou, Chin‐Rang Yang, Lihe Chen, Hyun Jun Jung, Kavee Limbutara, Benjamin Carter, Mark A. Knepper

The paper identifies PPAR activation as a key driver of compensatory renal proximal tubule hypertrophy using multi-omic analyses in a mouse model.

bioRxiv · Aug 29, 2022 · PreprintSystems Biology