Cancer BiologybioRxivPreprint
Senolytic targeting of CAF-induced KRT17+ colon cancer cells inhibits metastatic invasion
Daisuke Shiokawa, Hiroaki Sakai, Yusuke Kanda…·Koji Okamoto
This study identifies KRT17+ colon cancer cells driven by TGF-β1 from CAFs that promote metastasis and shows that targeting these cells with senolytics reduces invasion and metastasis in xenograft models.