Cancer BiologybioRxivPreprint
Dual MYC and GSPT1 Protein Degrader for MYC-Driven Cancers
Yuki Nishida, Valeria Impedovo, Edward Ayoub…·Michael Andreeff
This paper identifies a novel MYC-GSPT1 feedback loop and reports a dual degrader, GT19630, that effectively targets MYC-driven cancers with anti-proliferative and apoptotic effects.
DOI 10.1101/2025.04.24.650490