Author

Huan Sun

St. Jude Children's Research Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1 Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:database / resource· 2

Frequent Co-Authors

Gang YUiD· 3 shared Him K. ShresthaiD· 3 shared Jay M. YarbroiD· 3 shared Junmin PengiD· 3 shared Yun JiaoiD· 3 shared Zhiping WuiD· 3 shared Zuo-Fei YuaniD· 3 shared Anthony A. HighiD· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Gang YUORCID

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Author profile →

5 papers

Recent·Most cited

Schistosoma japonicum Histone Acetyltransferase 1 (SjHAT1): A Novel Anti-schistosomal Drug Target

Jing Xu, Yuxin Wang, Ping Cheong Huang, Yanan Zhang, Huan Sun, Tingzheng Zhan, Chao-Ming Xia

This paper identifies SjHAT1 as a potential drug target for schistosomiasis by showing its essential role in parasite survival and reproduction through functional and expression analyses.

PLoS Pathogens · Jun 24, 2026Peer-reviewedMicrobiology

Cell type-resolved proteomics reveals intra- and intercellular signalingin Alzheimers disease

Xue Zhang, Kaiwen Yu, Him K. Shrestha, Ying Zhou, Jiyuan Yang, Zhen Wang, Xiaokang Ren, Ping-Chung Chen, Huan Sun, Danting Liu, Yun Jiao, Jay M. Yarbro, Ju Wang, Zhiping Wu, Kiara Harper, , Junmin Peng

The paper presents a cell type-resolved proteomic atlas of Alzheimer's disease mouse models, identifying thousands of cell-specific protein changes and highlighting astrocyte-microglia signaling.

bioRxiv · Feb 4, 2026 · PreprintNeuroscience

Single Plaque Proteomics Reveals the Composition and Dynamics of the Amyloid Microenvironment in Alzheimer's Disease

Mengqi Chu, Ju Wang, Jay M. Yarbro, Ping-Chung Chen, Him K. Shrestha, Huan Sun, Mingming Niu, Zhen Wang, Sarah Harvey, Zhiping Wu, Yingxue Fu, Zuo-Fei Yuan, Tan Haiyan, Anthony A. High, Aijun Zhang, , Junmin Peng

The paper quantifies the proteomic composition of amyloid plaques in AD models and human brains, revealing stage-dependent remodeling and conserved proteins across species.

bioRxiv · Feb 4, 2026 · PreprintNeuroscience

Human-mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome

Jay M. Yarbro, Xian Han, Abhijit Dasgupta, Ka Yang, Danting Liu, Him K. Shrestha, Masihuz Zaman, Zhen Wang, Kaiwen Yu, Dong Geun Lee, David Vanderwall, Mingming Niu, Huan Sun, Boer Xie, Ping‐Chung Chen, , Junmin Peng

Alzheimer's mouse model proteomes capture 30% (amyloid-only models) to 42% (adding tau and splicing models) of consensus human AD protein changes; in 5xFAD, plaques slow degradation of plaque-associated proteins.

Nature Communications · Feb 11, 2025Peer-reviewedBiochemistry✦ In-depth digest

Engineering the ADDobody protein scaffold for generation of high-avidity ADDomer super-binders

Dora Buzas, Huan Sun, Christine Toelzer, Sathish K.N. Yadav, Ufuk Borucu, Gunjan Gautam, Kapil Gupta, Joshua C. Bufton, Julien Capin, Richard Barry Sessions, Frédéric Garzoni, Imre Berger, Christiane Schaffitzel

The paper engineers ADDobody protein scaffolds to generate high-avidity ADDomer super-binders through genetic modification and structural validation.

Structure · Jan 9, 2024Peer-reviewedSynthetic Biology