Single Plaque Proteomics Reveals the Composition and Dynamics of the Amyloid Microenvironment in Alzheimer's Disease
Mengqi Chu, Ju Wang, Jay M. Yarbro, Ping-Chung Chen, Him K. Shrestha, Huan Sun, Mingming Niu, Zhen Wang, Sarah Harvey, Zhiping Wu, Yingxue Fu, Zuo-Fei Yuan, Tan Haiyan, Anthony A. High, Aijun Zhang, , Junmin Peng
The paper quantifies the proteomic composition of amyloid plaques in AD models and human brains, revealing stage-dependent remodeling and conserved proteins across species.
bioRxiv · Feb 4, 2026 · PreprintNeuroscience