Author

Hugo Benoit

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:rat· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Assay:proteomics· 1

Frequent Co-Authors

Albano C. MéliiD· 2 shared Alain LacampagneiD· 1 shared Alessandro PorroiD· 1 shared Ana Maria GomeziD· 1 shared Andrea SaponaroiD· 1 shared Anna MoroniiD· 1 shared Atiyeh Sadat SharifzadehiD· 1 shared Dario DiFrancescoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPhysiology

Albano C. MéliORCID

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2 papers

Recent·Most cited

RyR2-Dependent Calcium Leak Drives the Acute Cardiovascular Manifestations of Ciguatera Poisoning: implications for an emerging climate-sensitive cardiotoxic disease

Hugo Benoit, Ismael Choukri, Pierre Sicard, Elisa Bounasri, Gilles Labesse, Laurie Alburquerque, Mohamed Laabir, Jacques G. Mercier, Jérôme Thireau, Alain Lacampagne, Albano C. Méli

This study identifies RyR2-dependent calcium leak as a mechanism underlying acute cardiovascular effects of ciguatoxin poisoning in human cardiomyocytes and rats.

bioRxiv · Sep 4, 2026 · PreprintPhysiology

Animal-free recombinant nanobody rescues HCN4 channel deficit in sinus node dysfunction

Atiyeh Sadat Sharifzadeh, Roberta Castelli, Alessandro Porro, Pietro Mesirca, Romain Perrier, Ana Maria Gomez, Hugo Benoit, Albano C. Méli, Luca Maria Giovanni Palloni, Dario DiFrancesco, Matteo Elia Mangoni, Gerhard Thiel, Andrea Saponaro, Anna Moroni

This study identifies a recombinant nanobody that specifically activates HCN4 channels and rescues sinus node dysfunction in a patient with a loss-of-function mutation.

bioRxiv · Mar 20, 2025 · PreprintBiophysics