Author

Hugo Lee

University of Wisconsin–Madison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1

Frequent Co-Authors

Feyza EnginiD· 3 shared Adwait Bhave· 1 shared Ajay H. ZalavadiaiD· 1 shared Anandwardhan A. HardikariD· 1 shared Aniruddha Pant· 1 shared Ashleigh E. SchafferiD· 1 shared Bo‐Jhih Guan· 1 shared Boaz TiroshiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersSystems Biology

Feyza EnginORCID

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Author profile →

3 papers

Recent·Most cited

Adaptation to chronic ER stress enforces pancreatic β-cell plasticity

Chien-Wen Chen, Bo‐Jhih Guan, Mohammed R. Alzahrani, Zhaofeng Gao, Long Gao, Syrena Bracey, Jing Wu, Cheikh A. Mbow, Raul Jobava, Leena Haataja, Ajay H. Zalavadia, Ashleigh E. Schaffer, Hugo Lee, Thomas LaFramboise, Ilya R. Bederman, , Maria Hatzoglou

This study shows chronic ER stress induces β-cell plasticity, but excessive stress leads to identity loss and is linked to T1D progression.

Nature Communications · Aug 8, 2022Peer-reviewedSystems Biology

Machine learning algorithms in big data analyses identify determinants of insulin gene transcription

Wilson K. M. Wong, Vinod Thorat, Mugdha V. Joglekar, Charlotte X. Dong, Hugo Lee, Yi Vee Chew, Adwait Bhave, Wayne J. Hawthorne, Feyza Engin, Aniruddha Pant, Louise T. Dalgaard, Sharda Bapat, Anandwardhan A. Hardikar

The paper compares 10 machine learning workflows to identify genes associated with insulin transcript presence in human pancreatic single-cell transcriptomes, finding Random Forest to be highly predictive.

bioRxiv · Mar 27, 2021 · PreprintGenetics

Differential expression of Ormdl genes in the islets of mice and humans with obesity

Hugo Lee, Rachel J. Fenske, Tugce Akcan, Elliot Domask, Dawn Belt Davis, Michelle E. Kimple, Feyza Engin

The paper examines Ormdl gene expression in islets from obese mice and humans, finding differential regulation and a role in beta-cell survival.

iScience · Jun 29, 2020Peer-reviewedMolecular Biology