Zhaofeng Gao

This study shows chronic ER stress induces β-cell plasticity, but excessive stress leads to identity loss and is linked to T1D progression.

The paper shows that cells use an adaptive pausing response to survive severe stress by pausing translation and limiting ATP use, followed by recovery through ISR signaling.

The paper identifies start-stop elements in 5' UTRs that repress translation by halting ribosomes, showing their prevalence in human genes and impact on cellular processes.

The paper identifies a Redox Thiol Switch (RTSGS) that regulates cellular energy metabolism by switching between S-glutathionylation and S-sulfhydration, with PCK2 as a novel target.