Molecular BiologybioRxivPreprint
Structural basis for alternative 3' splice site selection in the human spliceosome active center
Gabriele Marcianò, Simon Eckert, Luiza Zuvanonv…·Sebastian M. Fica
The paper presents cryo-EM structures of human spliceosomes showing how SDE2, FAM32A, and Prp18 regulate 3' splice site selection by counteracting distal bias and stabilizing weaker proximal sites.
DOI 10.64898/2026.08.05.741260