I. Amblard

Reciprocal regulation of Shh trafficking and H2O2 levels via a noncanonical BOC-Rac1 pathway

This study shows H2O2 levels regulate Shh trafficking and that Shh controls H2O2 synthesis via a noncanonical BOC-Rac1 pathway, impacting tissue patterning.

Bidirectional transfer of Engrailed homeoprotein across the plasma membrane requires PIP2

The paper demonstrates that PIP2 and cholesterol are essential for Engrailed2 homeoprotein translocation across the plasma membrane, with both secretion and internalization regulated by PIP2 levels.