VPg impact on Ryegrass mottle virus serine-like 3C protease proteolysis and structure
G. Kalnins, R. Ludviga, I. Kalnciema, G. Resevica, V. Zeltina, J. Bogans, K. Tars, A. Zeltins, I. Balke
This paper reports the first full crystal structure of RGMoV Pro with VPg cofactor, identifies a unique interaction site, and confirms a new cleavage site and inhibitory effects of Ca2+ and Zn2+.
bioRxiv · Jan 19, 2023Microbiology