X. Chang

Oolonghomobisflavans from Camellia sinensis disaggregate tau fibrils across Alzheimer's disease models

This study shows that Oolonghomobisflavans reduce tau fibrils and improve health in Alzheimer's models.

The Mechanism Insight into Bacterial Degradation of Pentachlorobiphenyl

This study identifies a new bacterium capable of degrading pentachlorobiphenyl and characterizes its enzymatic, proteomic, and metabolomic responses to the pollutant.

Protein language models-assisted engineering of Uracil-N glycosylase enables programmable T-to-G and T-to-C base editing

This study uses protein language models to engineer a uracil-N-glycosylase variant for programmable T-to-G and T-to-C base editing, achieving high success rates in correcting genetic mutations in mice.

Impaired aldehyde detoxification caused by a common human polymorphism promotes anti-bacterial immunity

The paper shows ALDH2 deficiency enhances anti-bacterial immunity by increasing aldehyde levels that kill pathogens and boost inflammatory responses.

Improving the solubility of pseudo-hydrophobic Alzheimer's Disease medicinal chemicals through co-crystal formulation

This study shows that forming salts of dihydromyricetin (DHM) improves its solubility and inhibitory activity against Alzheimer's disease tau, suggesting potential for medicinal chemistry applications.

Increased receptor affinity and reduced recognition by specific antibodies contribute to immune escape of SARS-CoV-2 variant Omicron

This study shows that SARS-CoV-2 Omicron escapes neutralizing antibodies through increased receptor affinity and reduced antibody recognition, while vaccines still provide some neutralization.

Virus-like particles (VLPs) are efficient tools for boosting mRNA-induced antibodies

This study compares antibody responses from homologous and heterologous prime-boost vaccination strategies using mRNA and VLP-based vaccines against SARS-CoV-2.

TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death

Intranasal administration of a VLP-based vaccine against COVID-19 induces neutralizing antibodies against SARS-CoV-2 and Variants of Concerns

This study evaluates an intranasally administered VLP-based vaccine in a murine model, showing strong systemic and mucosal antibody responses against SARS-CoV-2 and its variants.

Pancreatic Brsk2 amplifies parasympathetic signals to promote type 2 diabetes

This study shows Brsk2 amplifies parasympathetic signals to promote type 2 diabetes by enhancing β-cell insulin secretion in obese mice and associates human BRSK2 variants with metabolic disorders.

Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) Up to 15 Months Post-Infection

This study finds SARS-CoV-2 S1 protein in non-classical monocytes in PASC patients up to 15 months post-infection, but not full-length viral RNA.

KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype

This study shows KDM4 promotes epigenomic changes in senescent cells, enhances the SASP, and presents a therapeutic target for age-related diseases.

BNT162b2 mRNA COVID-19 vaccine induces antibodies of broader cross-reactivity than natural infection but recognition of mutant viruses is up to 10-fold reduced

This study compares antibody recognition of SARS-CoV-2 variants by natural infection and BNT162b2 vaccination, finding improved but reduced cross-reactivity against certain mutants.

SARS-CoV-2 variant with higher affinity to ACE2 shows reduced sera neutralization susceptibility

This study evaluates how mutations in the SARS-CoV-2 RBD affect ACE2 binding and neutralization by antibodies, finding increased affinity and reduced susceptibility to neutralization.

DNMT family induced down-regulation of NDRG1 via DNA methylation and clinicopathological significance in gastric cancer

The paper investigates the relationship between NDRG1 expression, DNA methylation, and DNMT family in gastric cancer, finding DNMT1 correlates with prognosis.

Screening, Identification and Growth Promotion Ability of Phosphate Solubilizing Bacteria from Soybean Rhizosphere under Maize-Soybean Intercropping Systems

This study isolates and identifies phosphate-solubilizing bacteria from soybean rhizosphere soil, finding strains that promote plant growth through organic acid secretion and indole acetic acid production.

The impact of size on particle drainage dynamics and antibody response

This study compares the draining kinetics and immunogenicity of round and rod-shaped VLPs, finding that round VLPs are more effective in antigen presentation and induce stronger immune responses.

JIB-04 has broad-spectrum antiviral activity and inhibits SARS-CoV-2 replication and coronavirus pathogenesis

The paper identifies JIB-04 as a broad-spectrum antiviral that inhibits SARS-CoV-2 replication and coronavirus pathogenesis in vitro and in vivo.

Development of a vaccine against the newly emerging COVID-19 virus based on the receptor binding domain displayed on virus-like particles

This study develops a vaccine candidate against SARS-CoV-2 using virus-like particles displaying the receptor binding domain, which induces neutralizing antibodies in mice.

Depression and Anxiety in Healthcare Staffs in A Tertiary University Hospital in Luoyang, Henan Province: A Cross-Sectional Observational Study

This study assesses depression and anxiety prevalence among healthcare staff in a Chinese hospital, identifying workplace violence and poor sleep as key risk factors.

Small-scale soil microbial community heterogeneity linked to landforms on King George Island, maritime Antarctica

The paper examines soil microbial community differences linked to landforms in Antarctica, finding that elemental compositions and environmental factors shape distinct microbial groups.