Formulating a TMEM176B blocker in nanoparticles uncouples its paradoxical roles in innate and adaptive antitumoral immunity.
S. Victoria, A. Castro, A. Pittini, D. Olivera, S. Russo, I. Cebrian, A. W. Mombru, E. Osinaga, H. Pardo, M. Segovia, M. Hill
This paper develops a nanoparticle formulation of BayK8644 that enhances its anti-tumoral efficacy by separating its dual effects on innate and adaptive immunity.
bioRxiv · Sep 2, 2022 · PreprintImmunology