A. Castro

Large language models overcome the challenges of unstructured text data in ecology

This study evaluates three large language models for automating ecological data extraction from text, finding GPT 4 performs best across tasks with high accuracy.

Integrated germline and somatic features reveal divergent immune pathways driving ICB response

This paper uses machine learning to predict ICB response by integrating germline and somatic features, revealing differences in immune pathways and clinical outcomes between MHC-I and MHC-II neoantigen reliant tumors.

An Alternatively Spliced Gain-of-Function NT5C2 Isoform Contributes to Chemoresistance in Acute Lymphoblastic Leukemia

The paper identifies an alternatively spliced NT5C2 isoform contributing to chemoresistance in B-ALL by enhancing nucleosidase activity and 6-MP resistance.

Cyclin A/cdk activity and FAM122A-dependent inhibition of PP2A-B55 are essential to trigger mitosis.

This study identifies FAM122A's role in inhibiting PP2A-B55 to initiate mitosis, showing its necessity in C. elegans and Xenopus systems.

Melanoma clonal subline analysis uncovers heterogeneity-driven immunotherapy resistance mechanisms

The paper analyzes melanoma clonal sublines to uncover how intratumoral heterogeneity drives resistance to immunotherapy.

Formulating a TMEM176B blocker in nanoparticles uncouples its paradoxical roles in innate and adaptive antitumoral immunity.

This paper develops a nanoparticle formulation of BayK8644 that enhances its anti-tumoral efficacy by separating its dual effects on innate and adaptive immunity.

Structure selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern

This study shows that structure-selected RBM immunogens induce polyclonal memory responses that neutralize SARS-CoV-2 variants of concern.

Cetacean "gas-bubble thromboembolic polycystic liver disease": "Budd-Chiari-like syndrome" in dolphins?

The paper reinterprets cystic liver lesions in cetaceans as Budd-Chiari-like syndrome caused by gas bubbles and pre-existing vascular disorders, not acoustic trauma.

Electrical signature of heterogeneous human mesenchymal stem cells

This study uses dielectrophoresis to quantify heterogeneity in human mesenchymal stem cells and links electrical properties to differentiation potential.

Autoimmune Alleles at the Major Histocompatibility Locus Modify Melanoma Susceptibility

This study shows that MHC-I autoimmune alleles are associated with reduced melanoma risk and later diagnosis age, independent of existing polygenic risk scores.

Structure and dynamics of FCHo2 docking on membranes

This study investigates how FCHo2 docks on membranes through molecular dynamics, showing PI(4,5)P2 facilitates its self-assembly and promotes clathrin assembly.

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

The paper identifies germline variants associated with the tumor immune microenvironment, linking them to cancer risk and immunotherapy response.

MHC-II constrains the natural neutralizing antibody response to the SARS-CoV-2 spike RBM in humans

The paper investigates how MHC-II constraints affect the generation of neutralizing antibodies against the SARS-CoV-2 spike RBM, finding poor peptide binding and potential cross-reactivity with microbial peptides.

Genome-wide identification, characterization and expression analysis of the Bcl-2 associated athanogene (BAG) gene family in Physcomitrium patens

This study identifies and characterizes BAG genes in Physcomitrium patens, revealing their potential roles in stress responses and highlighting their phylogenetic relationships and expression patterns.

Biocontrol potential of grapevine endophytes against grapevine trunk pathogens

This study isolates and evaluates endophytic and epiphytic fungi from Chilean grapevines to identify biocontrol agents against grapevine trunk pathogens, finding that Clonostachys rosea strains show strong inhibition of pathogens.

Risk factors associated with mortality in hospitalized patients with SARS-CoV-2 infection. A prospective, longitudinal, unicenter study in Reus, Spain

This study identifies risk factors for mortality in hospitalized SARS-CoV-2 patients in Spain, finding older age, fever, pneumonia, acute respiratory distress syndrome, diabetes, and cancer as significant predictors.