M. Hill

Maximum Likelihood Estimation for Unrooted 3-Leaf Trees: An Analytic Solution for the CFN Model

This paper provides a closed-form solution for maximum likelihood estimation of unrooted 3-leaf trees under the CFN model, characterizing when maximum likelihood estimates fail to exist.

Cooperativity and induced oligomerisation control the interaction of SARS- CoV-2 with its cellular receptor and patient-derived antibodies

The paper investigates how multivalent interactions between SARS-CoV-2 spike protein, ACE2 receptor, and patient-derived antibodies influence viral entry and antibody inhibition.

Pseudomonas aeruginosa senses and responds to epithelial potassium flux via Kdp operon to promote biofilm biogenesis

This study shows Pseudomonas aeruginosa uses potassium efflux from human airway epithelial cells to enhance biofilm formation through the KdpFABCDE system.

Sex differences in plasma, adipose tissue, and central accumulation of cannabinoids, and behavioural effects of oral cannabis consumption in male and female C57BL/6 mice.

This study examines sex differences in cannabinoid accumulation and behavioural effects of oral cannabis in mice, finding delayed pharmacokinetics and sex-specific behavioural responses.

Formulating a TMEM176B blocker in nanoparticles uncouples its paradoxical roles in innate and adaptive antitumoral immunity.

This paper develops a nanoparticle formulation of BayK8644 that enhances its anti-tumoral efficacy by separating its dual effects on innate and adaptive immunity.

SciCV, the Swiss National Science Foundation's new CV format

The paper evaluates the SciCV CV format introduced by the SNSF, finding it generally well-received but with mixed reactions to specific elements like metrics and publication lists.

A novel method accounting for predictor uncertainty and model transferability of invasive species distribution models

This paper introduces a method using multiple simple models to improve model transferability and account for predictor uncertainty in invasive species distribution models.

Genetic and immune landscape evolution defines subtypes of MMR deficient colorectal cancer

The paper identifies three subtypes of MMR deficient colorectal cancer based on genetic and immune landscape evolution, linking them to T-cell infiltrates and checkpoint-inhibitor resistance.

Sugar shock: Probing Streptococcus pyogenes metabolism through bioluminescence imaging

This study uses bioluminescence imaging to analyze how Streptococcus pyogenes metabolism responds to different carbon sources and environmental triggers.

On the Effect of Intralocus Recombination on Triplet-Based Species Tree Estimation

This paper shows that intralocus recombination creates an inconsistency zone in triplet-based species tree estimation, even with infinite data, and demonstrates this through simulations.

Ivermectin reduces coronavirus infection in vivo: a mouse experimental model

This study tests ivermectin's effect on coronavirus infection in mice, finding reduced viral load and liver damage compared to infected controls.

Freshwater sponge hosts and their green algae symbionts: a tractable model to understand intracellular symbiosis

This study examines the intracellular symbiosis between freshwater sponge Ephydatia muelleri and its green algal symbionts, identifying host responses and potential evolutionary pathways for stable mutualistic endosymbioses.

Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target

The paper reports the structure of human MANEA and inhibitor complexes, revealing its mechanism and informing the development of antiviral agents against bovine viral diarrhea and dengue viruses.

Fragmentation of extracellular ribosomes and tRNAs shapes the extracellular RNAome

The paper develops RI-SEC-seq to analyze nonvesicular exRNAs, revealing extracellular ribosomes and tRNAs that resist degradation and act as damage-associated molecular patterns.

Microbiome structure of ecologically important bioeroding sponges (family Clionaidae): The role of host phylogeny and environmental plasticity.

This study characterizes the microbiome of bioeroding sponges from the Clionaidae family, revealing species-specific core communities and environmental influences on microbial composition.

Sexual antagonism drives the displacement of polymorphism across gene regulatory cascades

The paper shows that sexual antagonism maintains polymorphism in gene expression only when intermediate levels are deleterious to both sexes and displaces it to upstream regulators over time.

Characterisation of deubiquitylating enzymes in the cellular response to high-LET ionising radiation and complex DNA damage

This study identifies USP6 as a key regulator of cell survival after high-LET radiation by stabilizing PARP-1, essential for repairing complex DNA damage.

Climate, human influence, and the distribution limits of the invasive European earwig, Forficula auricularia, in Australia

The paper models the distribution of the invasive European earwig in Australia, identifying climate and human influence as key factors affecting its range.