Author

I. Comas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Assay:whole-genome sequencing· 6 Approach:statistical model· 4 Research Focus:variant calling· 3 Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:DNA methylation· 1

Frequent Co-Authors

A. Chiner-Oms· 4 shared F. Gonzalez-Candelas· 2 shared A. Castaneda-Garcia· 1 shared A. Enciso-Moreno· 1 shared A. Gil-Brusola· 1 shared A. Martinez-Guarneros· 1 shared B. Cuevas-Cordoba· 1 shared B. Grau· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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4 shared papersMicrobiology

A. Chiner-Oms

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Genome data artifacts and functional studies of deletion repair in the BA.1 SARS-CoV-2 spike protein

M. Alvarez-Herrera, P. Ruiz-Rodriguez, B. Navarro-Dominguez, J. Zulaica, B. Grau, M. A. Bracho, M. Guerreiro, C. Aguilar-Gallardo, F. Gonzalez-Candelas, I. Comas, R. Geller, M. Coscolla

This study examines deletion repair in the BA.1 SARS-CoV-2 spike protein, finding that such events are rare and have limited direct impact on viral evolution but may influence fitness-enhancing mutations.

bioRxiv · Jan 23, 2024Evolutionary Biology

Selective pressure by rifampicin modulates mutation rates and evolutionary trajectories of mycobacterial genomes

E. Cebrian-Sastre, A. Chiner-Oms, R. Torres-Perez, I. Comas, J. C. Oliveros, J. Blazquez, A. Castaneda-Garcia

This study shows that rifampicin increases mutation rates in Mycobacterium smegmatis, leading to higher resistance and diverse evolutionary paths in hypermutable strains.

bioRxiv · Feb 1, 2023Microbiology

Gene Evolutionary Trajectories in M. tuberculosis Reveal Temporal Signs of Selection

A. Chiner-Oms, M. G. Lopez, I. Comas

The paper identifies gene evolutionary trajectories in M. tuberculosis strains to reveal past and present selective forces shaping their variability and drug resistance.

bioRxiv · Jul 15, 2021Evolutionary Biology

Towards next generation diagnostics for tuberculosis: identification of novel molecular targets by large-scale comparative genomics

G. A. Goig, M. Torres-Puente, C. Mariner Llicer, L. M. Villamayor, A. Chiner-Oms, A. Gil-Brusola, R. Borras, I. Comas

This study identifies 30 novel MTBC-specific genomic loci through comparative genomics and develops a qPCR assay for MTBC DNA quantification in clinical samples.

bioRxiv · Mar 6, 2019Microbiology

Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico

C. F. Madrazo-Moyza, I. Cancino-Munoz, B. Cuevas-Cordoba, V. Gonzalez-Covarrubias, M. Barbosa-Amezcua, X. Soberon, R. Muniz-Salazar, A. Martinez-Guarneros, C. Backer, J. Zarrabal-Meza, C. Sampieri-Ramirez, M. Lauzardo, A. Enciso-Moreno, I. Comas, R. Zenteno-Cuevas

This study evaluates the effectiveness of whole-genomic sequencing in predicting drug resistance in tuberculosis isolates from Mexico, showing high sensitivity and specificity for first-line drugs and identifying multidrug-resistant cases.

bioRxiv · Feb 15, 2019Microbiology

Genomic determinants of sympatric speciation of the Mycobacterium tuberculosis complex across evolutionary timescales.

A. Chiner-Oms, L. Sanchez-Buso, J. Corander, S. Gagneux, S. Harris, D. Young, F. Gonzalez-Candelas, I. Comas

This study identifies genomic factors driving sympatric speciation in Mycobacterium tuberculosis complex across evolutionary timescales, highlighting the role of phoR in virulence and adaptation.

bioRxiv · Nov 20, 2018Evolutionary Biology