D. Young

MAPK13 controls structural remodeling and disease after epithelial injury

This study identifies MAPK13 as a regulator of structural remodeling and disease after epithelial injury, showing its role in basal-epithelial stem cell hyperplasia and mucous metaplasia in both mouse and human models.

Chewing Through Challenges: Exploring the Evolutionary Pathways to Wood-Feeding in Insects

This paper investigates the evolutionary origins of saproxylophagy in insects, proposing the Detritivore-First Hypothesis and emphasizing the role of gut microbiomes in wood digestion.

Network-driven cancer cell avatars for combination discovery and biomarker identification for DNA Damage Response inhibitors

The paper introduces a network biology-driven simulation method to predict effective drug combinations and identify biomarkers for DNA Damage Response inhibitors using cancer cell avatars.

Patterns and determinants of the global herbivorous mycobiome

The paper analyzes AGF diversity across 661 fecal samples from 34 herbivorous species, identifying 56 novel genera and showing that both stochastic and deterministic processes shape AGF communities, with hindgut fermenters having stronger host-specific associations.

Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency

The paper evaluates TcE formats to determine how contact distance and flexibility affect their potency in forming immunological synapses.

Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection

This paper describes a monoclonal antibody, DZIF-10c, that effectively neutralizes SARS-CoV-2 and its variants when administered intranasally to mice, offering potential for topical treatment.

Lymph flow directs rapid neutrophil positioning in the lymph node in infection

This study shows that lymph flow directs neutrophil migration in lymph nodes during infection by transporting chemokines, and impaired flow leads to persistent infection.

Charge Interactions in a Highly Charge-depleted Protein

This study investigates charge interactions in a charge-depleted protein using simulations and experiments, revealing context-dependent residue interactions and their impact on protein stability.

Redox response of iron-sulfur glutaredoxin GRXS17 activates its holdase activity to protect plants from heat stress

This study identifies GRXS17 as a redox-regulated holdase that protects plants from heat stress by shifting its activity through Fe-S cluster oxidation.

Genomic determinants of sympatric speciation of the Mycobacterium tuberculosis complex across evolutionary timescales.

This study identifies genomic factors driving sympatric speciation in Mycobacterium tuberculosis complex across evolutionary timescales, highlighting the role of phoR in virulence and adaptation.

Dual RNAseq of human leprosy lesions identifies bacterial determinants linked to host immune response

The paper uses dual RNAseq to analyze leprosy lesions, linking bacterial states to host immune responses through type I IFNs and antibody pathways.