Selective pressure by rifampicin modulates mutation rates and evolutionary trajectories of mycobacterial genomes
E. Cebrian-Sastre, A. Chiner-Oms, R. Torres-Perez, I. Comas, J. C. Oliveros, J. Blazquez, A. Castaneda-Garcia
This study shows that rifampicin increases mutation rates in Mycobacterium smegmatis, leading to higher resistance and diverse evolutionary paths in hypermutable strains.
bioRxiv · Feb 1, 2023Microbiology