MicrobiologybioRxiv
Selective pressure by rifampicin modulates mutation rates and evolutionary trajectories of mycobacterial genomes
E. Cebrian-Sastre, A. Chiner-Oms, R. Torres-Perez…·A. Castaneda-Garcia
This study shows that rifampicin increases mutation rates in Mycobacterium smegmatis, leading to higher resistance and diverse evolutionary paths in hypermutable strains.
DOI 10.1128/spectrum.01017-23