Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling.
G. Giamundo, D. Intartaglia, E. Del Prete, E. Polishchuk, F. Andreone, M. Ognibene, S. Buonocore, B. Hay Mele, F. G. Salierno, J. Monfregola, D. Antonini, P. Grumati, A. Eva, R. De Cegli, I. Conte
The paper identifies Ezrin's role in regulating TSC complex activation at endosomes via EGFR-AKT signaling, showing its impact on mTORC1 and retinal function.
bioRxiv · May 3, 2024Cell Biology