C. Wilson

Proteomic profile analysis of plasma and aqueous humor from glaucoma and non-glaucomatous patients

This study compares proteomic profiles of aqueous humor and plasma between glaucoma and non-glaucomatous patients, identifying differentially abundant proteins linked to vascular integrity, inflammation, and neurodegeneration.

APP and β-amyloid modulate protein aggregation and dissociation from recycling endosomal and exosomal membranes

The paper shows APP and Aβ-peptides modulate protein aggregation and DCG biogenesis in Drosophila cells, with mutant Aβ-peptides disrupting these processes and causing AD-like pathologies.

Increased TRPV4 channel expression enhances and impairs blood vessel function in hypertension

This study shows that increased TRPV4 channel expression in endothelial cells both enhances and impairs vascular function in hypertension, leading to altered Ca2+ signaling and vascular reactivity.

Human neural rosettes secrete bioactive extracellular vesicles enriched in neuronal and glial cellular components

The paper shows human neural rosettes secrete extracellular vesicles containing neuronal and glial components that influence hiPSCs morphology and reduce SOX2 expression.

Metatranscriptomic analysis reveals synergistic activities of comammox and anammox bacteria in full-scale attached growth nitrogen removal system.

The paper investigates how dissolved oxygen affects the synergistic nitrogen removal by comammox and anammox bacteria in wastewater treatment systems.

Stress-induced Rab11a-exosomes induce AREG-mediated cetuximab resistance in colorectal cancer

This paper shows that stress-induced Rab11a-exosomes carrying AREG promote cetuximab resistance in colorectal cancer by activating EGFR signaling in KRAS-wild type cells.

Microbiota-dependent indole production is required for the development of collagen-induced arthritis

This study shows that microbiota-dependent indole production is essential for collagen-induced arthritis development and identifies potential therapeutic targets.

Modeling Sepsis-Associated ARDS Using a Lung Endothelial Microphysiological System

The paper uses a lung endothelial microphysiological system to study how sepsis plasma affects endothelial function, finding increased permeability and inflammatory markers.

Sperm Cell Painting: A Mechanism Driven Approach for Drug Discovery in Human Spermatozoa

This paper adapts a cell painting assay to human spermatozoa to create an image-based fingerprint for studying compound effects on sperm function and contraceptive discovery.

Role of trafficking protein particle complex 2 in medaka development

This study generates a medaka model for Spondyloepiphyseal Dysplasia Tarda by knocking out TRAPPC2, revealing developmental defects similar to human SEDT.

ParSe 2.0: A web application that enables proteome-scale searches for sequences that drive protein-mediated phase separation

ParSe 2.0 predicts protein regions that drive phase separation using sequence-based descriptors and is available as a web application.

Sperm Toolbox - A selection of small molecules to study human spermatozoa

The paper establishes a small molecule library for studying human spermatozoa and provides a dataset for comparing compound effects and assays.

A Rab6 to Rab11 transition is required for dense-core granule and exosome biogenesis in Drosophila secondary cells

The paper studies DCG biogenesis in Drosophila secondary cells, identifying a Rab6 to Rab11 transition essential for DCG and exosome formation.

Co-occurrence and cooperation between comammox and anammox bacteria in a full-scale attached growth municipal wastewater treatment process.

The paper reports co-occurrence and cooperation between comammox and anammox bacteria in a full-scale wastewater treatment system, showing dissolved oxygen-dependent nitrogen loss.

Low diversity and microdiversity of comammox bacteria in wastewater systems suggests wastewater-specific adaptation within the Ca. Nitrospira nitrosa cluster.

The paper compares diversity and microdiversity of comammox bacteria with strict nitrifiers in wastewater systems, finding low diversity and specific adaptations in comammox populations.

High Expression of Glycolytic Genes in Clinical Glioblastoma Patients Correlates with Lower Survival

This study finds that high expression of glycolytic genes like HK2 and PKM2 in GBM correlates with poor patient survival, while mitochondrial metabolism genes are increased in GBM compared to LGG but lower than normal brain.

Compounds enhancing human sperm motility identified using a high-throughput phenotypic screening platform

A high-throughput screening platform identified 105 compounds that enhance human sperm motility, including novel targets like GABA signaling and PDE10A inhibitors.

Mitochondrial ATP production is required for endothelial cell control of vascular tone

This study shows that mitochondrial ATP production is essential for endothelial cell regulation of vascular tone across species, affecting calcium activity and nitric oxide signaling.

Exploring the cytotoxic mechanisms of Pediocin PA-1 towards HeLa and HT29 cells by comparison to known bacteriocins: Microcin E492, Enterocin Heterodimer and Divercin V41.

This study investigates Pediocin PA-1's cytotoxic mechanisms against HeLa and HT29 cells by comparing it to Microcin E492, Enterocin Heterodimer, and Divercin V41, suggesting TLR4 interaction and apoptosis.

Rbf/E2F1 control growth and endoreplication via steroid-independent Ecdysone Receptor signalling in Drosophila prostate-like secondary cells

This study shows that Rbf/E2F1 and cell cycle regulators control growth and endoreplication in Drosophila secondary cells via steroid-independent EcR signalling, mirroring mechanisms in castration-resistant prostate cancer.

Computer code comprehension shares neural resources with formal logical inference in the fronto-parietal network

The paper investigates the neural basis of code comprehension and finds it shares resources with formal logical inference in the fronto-parietal network.

Bimodal evolution of Src and Abl kinase substrate specificity revealed using mammalian cell extract as substrate pool

This study reveals the bimodal evolution of Src and Abl kinase substrate specificity using mammalian cell extract as a substrate pool, showing divergent evolutionary paths leading to specific and promiscuous enzymes.

The developmental and genetic architecture of the sexually selected male ornament of swordtails

The paper identifies genes associated with sword development in swordtail fish by analyzing transcriptional profiles and genetic mapping.

Accessory ESCRT-III proteins selectively regulate Rab11-exosome biogenesis in Drosophila secondary cells

This study identifies accessory ESCRT-III proteins as essential for Rab11-exosome biogenesis in Drosophila secondary cells, distinct from core ESCRT functions.

Modeling cell turning by mechanics at the cell rear

The paper models cell turning by incorporating mechanosensitive adhesions into a mechanical model of keratocyte motility, showing how this affects cell behavior compared to uniform adhesion.

Limited transgenerational effects of environmental temperatures on thermal performance of a cold-adapted salmonid

This study examines transgenerational plasticity in lake trout, finding that offspring performance reflects parental environmental conditions but can be detrimental when environments mismatch.

Disrupted Endothelial Cell Heterogeneity and Network Organization Impairs Vascular Function in Prediabetic Obesity

This study shows that disrupted endothelial cell heterogeneity and network organization in prediabetic obesity impair vascular function by altering calcium signaling and communication patterns.

Drosophila Sex Peptide Controls the Assembly of Lipid Microcarriers in Seminal Fluid

This paper shows that Sex Peptide in Drosophila is essential for assembling lipid microcarriers in seminal fluid, which are transferred to females and disassembled, with SP also required for normal female disassembly.

Glutamine deprivation regulates the origin and function of cancer cell exosomes

This study shows that glutamine deprivation increases exosome release from cancer cells, which promote tumor growth and blood vessel networks through Rab11a-dependent mechanisms.

Root production in a subtropical pasture is mediated by cultivar and defoliation severity

This study examines how cultivar and defoliation severity affect root and shoot production in a pasture grass, finding weak coupling between aboveground and belowground productivity.