Author

I. Efremenko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Organism:zebrafish· 1

Frequent Co-Authors

I. Silman· 1 shared J. L. Sussman· 1 shared J. M. L. Martin· 1 shared N. B. Chandar· 1 shared

Activity by Year

2019-2019 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperBiophysics

I. Silman

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1 paper

Recent·Most cited

Molecular Dynamics Simulations of the Interaction of Mouse and Torpedo Acetylcholinesterase with Covalent Inhibitors Explain Their Differential Reactivity: Implications for Drug Design

N. B. Chandar, I. Efremenko, I. Silman, J. M. L. Martin, J. L. Sussman

This paper uses molecular dynamics simulations to explain why mouse and Torpedo acetylcholinesterase differ in reactivity to covalent inhibitors, highlighting the importance of enzyme flexibility in drug design.

bioRxiv · Jan 28, 2019Biophysics