I. Ferrer

CD4+ tumor-infiltrating lymphocytes secreting T cell-engagers induce regression of autologous patient-derived non-small cell lung cancer xenografts

This study shows that engineered CD4+ TIL secreting TCE can induce tumor regression in NSCLC PDX models by redirecting non-tumor dominant T cell clones.

MDM2 stabilization of Notch intracellular domain upon DNA damage plays a major role in non-small cell lung carcinoma response to platinum chemotherapy

This study identifies MDM2 stabilization of NICD in response to platinum chemotherapy in NSCLC, showing that targeting MDM2 and NICD improves survival and reduces tumor growth.

A cell-autonomous mechanism regulates BCAA catabolism in white adipocytes and systemic metabolic balance.

This study identifies ankyrin-B's role in regulating BCAA catabolism in white adipocytes, linking its deficiency to elevated plasma BCAAs and metabolic dysfunction.

Farnesyltransferase inhibition overcomes the adaptive resistance to osimertinib in EGFR-mutant NSCLC

This study identifies early escapers as a rare cell population resistant to EGFR-TKi and shows that tipifarnib overcomes this resistance by targeting Rho/ROCK pathway and preventing relapse.