Author

I. Hoffmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Musacchio· 2 shared D. Vogt· 2 shared M. E. Pesenti· 2 shared A. Kordonsky· 1 shared A. Maestro· 1 shared A. Santamaria· 1 shared A.-S. Kratz· 1 shared B. Mulay· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

A. Musacchio

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Interactions with multiple inner kinetochore proteins determine mitotic localization of FACT

J. Schweighofer, B. Mulay, I. Hoffmann, D. Vogt, M. E. Pesenti, A. Musacchio

This study identifies multiple CCAN binding sites and shows that FACT localization to kinetochores depends on specific CCAN subcomplexes and is regulated by CK2 phosphorylation and DNA displacement.

bioRxiv · Jun 14, 2024Biochemistry

The CUL4-DDB1-DCAF1 E3 ubiquitin ligase complex regulates PLK4 protein levels to prevent premature centriole duplication

J. Grossmann, A.-S. Kratz, A. Kordonsky, G. Prag, I. Hoffmann

The paper shows that the CUL4-DDB1-DCAF1 E3 ligase complex targets PLK4 for degradation in G2 phase to prevent premature centriole duplication.

bioRxiv · Sep 13, 2023 · PreprintCell Biology

Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization

M. E. Pesenti, T. Raisch, D. Conti, I. Hoffmann, D. Vogt, D. Prumbaum, I. R. Vetter, S. Raunser, A. Musacchio

The paper reports a cryo-EM structure of the human CCAN complex and discusses its implications for CENP-A nucleosome recognition and centromere organization.

bioRxiv · Jan 6, 2022Biochemistry

Strikingly different roles of SARS-CoV-2 fusion peptides uncovered by neutron scattering

A. Santamaria, K. C. Batchu, O. Matsarskaia, S. F. Prevost, D. Russo, F. Natali, T. Seydel, I. Hoffmann, V. Laux, M. Haertlein, T. A. Darwish, R. A. Russell, G. Corucci, G. Fragneto, A. Maestro, N. R. Zaccai

This study uses neutron scattering to reveal how calcium and cholesterol influence the SARS-CoV-2 Spike protein's role in membrane fusion during viral entry.

bioRxiv · Aug 30, 2021Biophysics

FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation

I. Hoffmann, K. T. Richter, Y. T. Kschonsak, B. Vodicska

The paper identifies FBXO45-MYCBP2 as an E3 ubiquitin ligase that degrades FBXW7 during prolonged mitotic arrest, promoting mitotic slippage and chemoresistance.

bioRxiv · Mar 20, 2019Cell Biology