J. Grossmann

The CUL4-DDB1-DCAF1 E3 ubiquitin ligase complex regulates PLK4 protein levels to prevent premature centriole duplication

The paper shows that the CUL4-DDB1-DCAF1 E3 ligase complex targets PLK4 for degradation in G2 phase to prevent premature centriole duplication.

Haptoglobin buffers lipopolysaccharides to safeguard against aberrant NFκB activation

This study shows haptoglobin binds and buffers lipopolysaccharides to delay NFκB activation in macrophages, suggesting its role in preventing aberrant inflammation.

Slice-PASEF: Maximising Ion Utilisation in LC-MS Proteomics

Slice-PASEF improves tandem MS sensitivity for low-sample proteomics, enabling applications like single-cell proteomics and drug screens.

Rapid and strain-specific resistance evolution of Staphylococcus aureus against inhibitory molecules secreted by Pseudomonas aeruginosa

This study shows S. aureus rapidly evolves resistance to P. aeruginosa inhibitory molecules through strain-specific mutations in membrane transporters and virulence trait up-regulation.

Diurnal Dynamics of the Arabidopsis Rosette Proteome and Phosphoproteome

The paper quantifies diurnal changes in the Arabidopsis rosette proteome and phosphoproteome, revealing proteins and phosphorylation sites involved in light-dark transitions and cellular processes.

Naive orangutans (Pongo abelii & Pongo pygmaeus) individually acquire nut-cracking using hammer tools

This study shows that naive orangutans can spontaneously learn to crack nuts with hammers through individual and non-copying social learning, expanding the known species capable of this behavior.