Cell BiologybioRxiv
FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation
I. Hoffmann, K. T. Richter, Y. T. Kschonsak, B. Vodicska
The paper identifies FBXO45-MYCBP2 as an E3 ubiquitin ligase that degrades FBXW7 during prolonged mitotic arrest, promoting mitotic slippage and chemoresistance.
DOI 10.1038/s41418-019-0385-7