Author

I. L. Co

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. P. McGuigan· 2 shared J. L. Cadavid· 2 shared N. Landon-Brace· 2 shared A. Fomina· 1 shared B. T. Innes· 1 shared C. Tam· 1 shared C. Yu· 1 shared F. Notta· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

A. P. McGuigan

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2 papers

Recent·Most cited

Single-cell analysis of an engineered organoid-based model of pancreatic cancer identifies hypoxia as a contributing factor in the determination of transcriptional subtypes

N. Landon-Brace, B. T. Innes, S. Latour, J. L. Cadavid, I. L. Co, C. Tam, F. Nowlan, S. Drissler, F. Notta, H. W. Jackson, G. D. Bader, A. P. McGuigan

This study uses single-cell transcriptomics to show that hypoxia in organoid models influences transcriptional subtypes in pancreatic cancer.

bioRxiv · Mar 5, 2024 · PreprintCancer Biology

An Engineered 3D Co-culture Model of Primary Macrophages and Patient-Derived Tumour Cells to Explore Cellular Responses in the Graded Hypoxic Microenvironment of Pancreatic Cancer

I. L. Co, C. Yu, S. Lamorte, M. T. Ciudad, N. Landon-Brace, J. L. Cadavid, Z. Xia, A. Fomina, M. Nurse, T. L. McGaha, K. R. Campbell, A. P. McGuigan

This paper develops a 3D co-culture model of macrophages and PDAC organoids to study hypoxia-driven cellular interactions and their impact on chemoresistance and immune responses.

bioRxiv · Jul 13, 2023 · PreprintBioengineering