C. Yu

A Host Enzyme Reduces Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Inactivating Intestinal Lipopolysaccharide

This study shows that AOAH inactivates intestinal LPS, reducing MASLD by preventing hepatic lipid accumulation and altering lipid metabolism gene expression.

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes

This paper introduces PRISM, a method for high-plex spatial RNA imaging using color intensity barcodes, validated across multiple tissues and showing the role of CAFs in tumor microenvironments.

A vacuolar invertase gene SlVI modulates sugar metabolism and postharvest fruit quality and resistance in tomato

This study investigates the role of the tomato vacuolar invertase gene SlVI in sugar metabolism, fruit quality, and postharvest resistance, finding that its knockout increases sucrose content, firmness, and resistance to Botrytis cinerea.

ROS Mediated the Photodynamic Antibacterial of Vibrio vulnificus by a DNA-Targeted Molecular Rotor Probe

This paper introduces a novel fluorescent probe, BDTP, that effectively kills Vibrio vulnificus through photodynamic antibacterial activity and promotes wound healing in an animal model.

Single-Cell Transcriptomic Profiling Unveils Critical Metabolic Alterations and Signatures in Progression of Atherosclerosis

This study uses single-cell RNA sequencing to identify metabolic changes and gene signatures in atherosclerosis progression, revealing altered metabolic pathways and cell-cell interactions.

Morroniside promotes skin wound re-epithelialization by facilitating epidermal stem cell proliferation through GLP-1R-mediated upregulation of β-catenin expression

This study shows that morroniside promotes skin wound healing by enhancing epidermal stem cell proliferation through GLP-1R-mediated upregulation of β-catenin and downstream targets.

Climate change has desynchronized insect and vegetation phenologies across Europe

The paper examines phenological shifts in European vegetation and herbivorous insects over 34 years, finding that 61.2% have become asynchronous, with vegetation advancing faster than insects.

An automatic glaucoma grading method based on attention mechanism and EfficientNetB3 network

This paper improves glaucoma grading by combining 2D fundus images and 3D OCT data with EfficientNet-B3 and ResNet34 models, using an attention mechanism to reduce feature redundancy.

Strong cascading impacts of micropollutants on planktonic food web in urban river

This study examines how micropollutants affect planktonic food webs in urban rivers, finding stronger impacts in more urbanized areas with algal-mediated cascading effects.

Proximity Labeling Expansion Microscopy (PL-ExM) resolves structure of the interactome

PL-ExM combines proximity labeling and expansion microscopy to visualize 3D interactome structures and assess PL technique performance.

AI in Paleontology

This paper reviews AI applications in paleontology, highlighting a gap between paleontological AI and mainstream AI studies, and discusses future directions for integrating AI into paleontological research.

Disordered C-terminal domain drives spatiotemporal confinement of RNAPII to enhance search for chromatin targets

The paper shows that the disordered C-terminal domain of RNAPII confines its diffusion to a subnuclear region, enhancing target search efficiency in yeast.

Dynamic simulations of feeding and respiration of the early Cambrian periderm-bearing cnidarian polyps

This study simulates the feeding and respiration of early Cambrian cnidarian polyps using CFD to show how muscle contractions drive water flow, supporting hypotheses about ancestral medusozoan behavior.

Microglia at Sites of Atrophy Restrict the Progression of Retinal Degeneration via Galectin-3 and Trem2 Interactions

The paper identifies a common neuroprotective response of microglia at retinal atrophy sites in mice and humans, mediated by galectin-3 and Trem2 interactions.

An Engineered 3D Co-culture Model of Primary Macrophages and Patient-Derived Tumour Cells to Explore Cellular Responses in the Graded Hypoxic Microenvironment of Pancreatic Cancer

This paper develops a 3D co-culture model of macrophages and PDAC organoids to study hypoxia-driven cellular interactions and their impact on chemoresistance and immune responses.

GDF15 is a Critical Renostat in the Defense Against Hypoglycemia

This study identifies GDF15 as a new hypoglycemia counterregulatory hormone, showing it increases hepatic gluconeogenesis through renal release and beta-adrenergic receptor-2 signaling.

An evolutionary epigenetic clock in plants

This paper introduces an epigenetic clock based on stochastic DNA methylation changes in plants, enabling high-resolution temporal analysis of phylogenetic relationships.

An innate granuloma eradicates an environmental pathogen using Gsdmd and Nos2

This study identifies a novel granuloma model in mice induced by Chromobacterium violaceum, showing that innate immune mechanisms can eradicate an environmental pathogen without adaptive immunity.

Single-Cell Map of Dynamic Multicellular Ecosystem of Radiation-Induced Intestinal Injury

This study maps the dynamic multicellular ecosystem of radiation-induced intestinal injury using single-cell RNA sequencing, revealing heterogeneous radiosensitivities and cellular interactions.

Angiopoietin-like 4 promotes the proliferation and migration of epidermal stem cells and contributes to the re-epithelialization of cutaneous wounds

This study shows ANGPTL4 promotes epidermal stem cell proliferation and migration, enhancing wound re-epithelialization in mice.

Quantitative classification of energy landscapes inferred from single nanoparticle tracking of membrane receptors inside nanodomains reveals confinement functional and molecular features

The paper quantitatively classifies energy landscapes of membrane receptors using single nanoparticle tracking and computational methods, revealing two distinct confinement mechanisms.

Preclinical Basis of the Efficacy and Pharmacodynamics of Finotonlimab, a Humanized Anti-PD-1 Monoclonal Antibody with Potent Implications for Clinical Benefit

This paper evaluates the preclinical efficacy and pharmacodynamics of Finotonlimab, a humanized anti-PD-1 antibody, showing high PD-1 binding affinity and sustained receptor occupancy in cynomolgus monkeys.

Acyl-CoA dehydrogenase substrate promiscuity limits the potential for development of substrate reduction therapy in disorders of valine and isoleucine metabolism

This study investigates whether inhibiting ACAD8 and SBCAD can reduce toxic metabolite accumulation in valine and isoleucine metabolism disorders, finding that MCPA inhibits multiple ACADs and partially rescues lipoylation defects in ECHS1-deficient cells.

Monkeypox virus quadrivalent mRNA vaccine induces antibody responses and cellular immunity and protects mice against Vaccinia virus

This study develops two quadrivalent mRNA vaccines against monkeypox virus and shows they induce antibodies, cellular immunity, and protection against Vaccinia virus in mice.

Structural surfaceomics reveals an AML-specific conformation of Integrin-β2 as a CAR-T therapy target

The paper identifies an AML-specific conformation of Integrin-β2 using structural surfaceomics and demonstrates its targeting by CAR-T cells.

Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against Omicron

This study identifies antibodies effective against Omicron by analyzing epitope changes and binding patterns, showing their ability to neutralize the virus through a conserved mechanism.

Genetically encoded photocatalytic protein labeling enables spatially-resolved profiling of intracellular proteome

The paper introduces a method to label and profile subcellular proteins in living cells using a genetically encoded photocatalyst and reactive probes, achieving high specificity in mitochondrial proteome analysis.

ADOLESCENT EXPOSURE TO LOW-DOSE THC DISRUPTS ENERGY BALANCE AND ADIPOSE ORGAN HOMEOSTASIS IN ADULTHOOD

This study shows that adolescent exposure to low-dose THC leads to metabolic changes in adulthood, including reduced fat mass and adipose dysfunction.

Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1

The paper characterizes the human LOR domain of AASS, presents its crystal structure, and identifies it as a potential drug target for glutaric aciduria type 1.