A. P. McGuigan

This study identifies EHMT2 as a key regulator of CAF hyperproliferation and pro-invasive behavior, showing its inhibition reprograms CAFs to a less aggressive state.

This paper develops a 3D co-culture model of macrophages and PDAC organoids to study hypoxia-driven cellular interactions and their impact on chemoresistance and immune responses.

The paper introduces a 96-well mini-MEndR assay to co-evaluate human and mouse Pax7+ cell-mediated skeletal muscle repair, demonstrating its utility for drug screening and phenotypic analysis.

This paper introduces an automated workflow for generating and analyzing 3D tumor-mimetic microtissues using the SPOT platform, enabling high-throughput screening and single-cell analysis of patient-derived organoids.

This paper introduces a high-throughput platform for generating standardized organoid microtissues to enable drug screening and phenotypic assays.

This paper develops a 3D in vitro model of human adipocytes to study fatty acid-induced obesity and its associated pathologies.

REVOLVER is a low-cost automated protein purification system that enables parallel processing with minimal human intervention, achieving results comparable to manual methods.

GLAnCE is a hydrogel platform that enables real-time observation of CAF-tumour cell interactions at the tumour-stroma interface, revealing interface-specific invasion and EMT gene induction.