Z. Xia

Altered liver metabolism post-wean abolishes efficacy of vitamin D for breast cancer prevention in a mouse model

This study shows that vitamin D's anti-cancer effects are reduced in post-wean mice due to altered liver metabolism, highlighting the importance of reproductive history in treatment efficacy.

Androgen receptor activity inversely correlates with immune cell infiltration and immunotherapy response across multiple cancer lineages

The paper examines the relationship between androgen receptor activity and immune cell infiltration, showing that lower AR activity correlates with increased immune activity and better immunotherapy response across multiple cancers.

Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging process

The paper constructs a transcriptomic atlas of immune cells across human lifespan and develops a biological age prediction model using scRNA-seq and bulk RNA-seq data.

Insight into the gut virome in patients with multiple sclerosis

This study examines the gut virome in MS patients, finding reduced diversity and specific taxonomic changes compared to healthy controls.

Attila and Aetius on the roof: The succession phenomenon in the roof greening area of a primary school in Beijing during the lockdown period of the COVID-19

The paper examines changes in rooftop green areas of a primary school in Beijing before and during the COVID-19 lockdown, focusing on invasive weed succession and its impact on cultivated plants.

Androgen blockade primes NLRP3 in macrophages to induce tumor phagocytosis

This study shows that androgen blockade increases NLRP3 in macrophages, which when combined with NLRP3 agonist, enhances cancer cell phagocytosis and tumor control in a mouse model of prostate cancer.

An Engineered 3D Co-culture Model of Primary Macrophages and Patient-Derived Tumour Cells to Explore Cellular Responses in the Graded Hypoxic Microenvironment of Pancreatic Cancer

This paper develops a 3D co-culture model of macrophages and PDAC organoids to study hypoxia-driven cellular interactions and their impact on chemoresistance and immune responses.

The Evidence of Cough Contagion in Human Beings

This study provides evidence that cough contagion in humans is driven by empathy, not physiology, showing no time difference and gender-based susceptibility.

Augmentation of Histone Deacetylase 6 Activity Impairs Mitochondrial Respiratory Complex I in Ischemic/Reperfused Diabetic Hearts

This study shows that increasing HDAC6 activity impairs mitochondrial complex I in diabetic hearts subjected to ischemia/reperfusion, and that inhibiting HDAC6 improves cardiac function.

Natural Killer cell contractility and cytotoxicity is driven by TLR3 agonist-mediated TAZ cytoplasmic sequestration

This study shows that TLR3 agonist hiltonol sequesters TAZ in NK cells, enhancing cytotoxicity by increasing contractility and reducing inhibitory receptors.

Integrated transcriptome and lineage analyses reveal novel catecholaminergic cardiomyocytes contributing to the cardiac conduction system in murine heart

This study identifies a novel catecholaminergic cardiomyocyte population expressing Dbh that contributes to the murine cardiac conduction system through transcriptomic, genetic, and optogenetic analyses.

Zinc Finger MYND-Type Containing 8 (ZMYND8) is epigenetically regulated in mutant Isocitrate Dehydrogenase 1 (IDH1) glioma to promote radioresistance

This paper identifies ZMYND8 as a gene epigenetically regulated by mIDH1 that promotes radioresistance in glioma cells, and shows its knockdown enhances radiosensitivity.

Staphylococcus aureus nt5 gene contributes to bacterial infection ability to form kidney abscess

This study shows that silencing the nt5 gene in Staphylococcus aureus reduces kidney abscess formation and enhances phagocytosis by host immune cells.

AN ECONOMIC, SQUARE-SHAPED FLAT-FIELD ILLUMINATION MODULE FOR TIRF-BASED SUPER-RESOLUTION MICROSCOPY

The paper introduces a cost-effective flat-field illumination module for TIRF-based super-resolution microscopy to address uneven illumination issues.

An atlas of human viruses provides new insights into diversity and tissue tropism of human viruses

The paper curates an atlas of human viruses, revealing increased diversity in infants and factors influencing tissue tropism, while introducing the Human Virus Database.

Mesenchymal Lineage Heterogeneity Underlies Non-Redundant Functions of Pancreatic Cancer-Associated Fibroblasts

The paper identifies a minor subset of pancreatic cancer-associated fibroblasts (CAFs) derived from pancreatic stellate cells (PSCs) that have non-redundant functions in shaping the tumor microenvironment.

Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and FlipGFP-based reporter assay

This study identifies potent SARS-CoV-2 PLpro inhibitors through high-throughput screening and a FlipGFP-based assay, showing improved antiviral activity compared to existing compounds.

exosome-LncPICALM-AU1 regulates endothelial-mesenchymal transition in hepatopulmonary syndrome

This study identifies exosomal lncRNA PICALM-AU1 from cholangiocytes as a key regulator of endothelial-mesenchymal transition in hepatopulmonary syndrome, with potential as a biomarker and therapeutic target.

Resiniferatoxin (RTX) ameliorates acute respiratory distress syndrome (ARDS) in a rodent model of lung injury

This study shows that RTX reduces lung inflammation and edema in a rodent model of ALI by targeting cardiopulmonary spinal afferents.

TGF-β signaling is critical for maintenance of the tendon cell fate

This study shows TGF-β signaling is essential for maintaining tendon cell identity, as its disruption leads to dedifferentiation and loss of markers in tenocytes.

Electrochemical Roughening and Carbon Nanotube Coating of Tetrodes for Chronic Single-Unit Recording

This paper develops a tetrode probe with electrochemical roughening and carbon nanotube coating to enable long-term, high-quality single-unit recordings in rodent and primate brains.

Variation in assembly stoichiometry in non-metazoan homologs of the hub domain of Ca2+/Calmodulin-dependent protein kinase II

The paper shows that hub domain assemblies of CaMKII-like proteins in green algae form larger oligomers than metazoan homologs, and that sequence changes can alter assembly stoichiometry.

Transcriptome analysis of the Molecular Mechanism underlying Immunity- and Reproduction trade-off in Locusta migratoria Infected by Micrococcus luteus

This study investigates the trade-off between immunity and reproduction in locusts by analyzing transcriptome changes in response to bacterial infection.

Membrane proteins with high N-glycosylation, high expression, and multiple interaction partners were preferred by mammalian viruses as receptors

The paper curates a database of virus-host receptor interactions and identifies common features of viral receptors, showing their role in cross-species transmission.