Author

I. L. Scott

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Snow· 1 shared F. M. Harsini· 1 shared G. A. Cornwall· 1 shared J. Williams· 1 shared K. L. Fuson· 1 shared M. J. Dominguez· 1 shared P. A. Keyel· 1 shared P. Bhattacharjee· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

A. Snow

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1 paper

Recent·Most cited

Pathogenic Mutations in the C2A Domain of Dysferlin form Amyloid that Activates the Inflammasome.

I. L. Scott, M. J. Dominguez, A. Snow, F. M. Harsini, J. Williams, K. L. Fuson, R. Thapa, P. Bhattacharjee, G. A. Cornwall, P. A. Keyel, R. B. Sutton

This study shows that C2A domain mutations in dysferlin cause amyloid formation, which activates the NLRP3 inflammasome and leads to inflammation and muscle dysfunction in Limb-Girdle Muscular Dystrophy Type-2B/2R.

bioRxiv · Apr 24, 2023 · PreprintBiophysics