R. B. Sutton

The Mouse Epididymal Amyloid Matrix: A Mammalian Counterpart of a Bacterial Biofilm

The paper identifies the mouse epididymal amyloid matrix as a structural and functional analog of bacterial biofilms, protecting spermatozoa through components like eDNA, eRNA, and mucin-like polysaccharides.

Pathogenic Mutations in the C2A Domain of Dysferlin form Amyloid that Activates the Inflammasome.

This study shows that C2A domain mutations in dysferlin cause amyloid formation, which activates the NLRP3 inflammasome and leads to inflammation and muscle dysfunction in Limb-Girdle Muscular Dystrophy Type-2B/2R.

Deficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in mice

This study shows that reducing macrophage-derived Dnase1L3 in mice causes mild lupus-like symptoms, suggesting its role in preventing lupus.

Mechanism of dual pharmacological correction and potentiation of human CFTR

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

Structural features of Dnase1L3 responsible for serum antigen clearance

This study identifies structural features of Dnase1L3 that enable its unique ability to degrade antigenic DNA complexes, preventing autoimmunity.

Redefining the architecture of ferlin proteins: insights into multi-domain protein structure and function

The paper uses RoseTTAFold and AlphaFold2 to model human ferlin proteins, revealing a previously unknown C2 domain, C2-FerA, and consistent domain structures across ferlin proteins.

Tumor-Antagonizing Fibroblasts Secrete Prolargin as Tumor Suppressor in Hepatocellular Carcinoma

The paper identifies prolargin as a tumor suppressor secreted by tumor-antagonizing fibroblasts in HCC, showing its correlation with patient outcomes and its inhibition of tumor progression.