SERCA2 regulates proinsulin processing and processing enzyme maturation in the pancreatic β cell
H. Iida, T. M. Kono, C.-C. Lee, P. Krishnan, M. C. Arvin, S. A. Weaver, T. S. Jarvela, R. N. Bone, X. Tong, P. Arvan, I. Lindberg, C. Evans-Molina
This study identifies SERCA2 as a regulator of proinsulin processing and processing enzyme maturation in pancreatic β cells, linking ER Ca2+ levels to impaired glucose tolerance in diabetes.
bioRxiv · Jun 13, 2022 · PreprintPhysiology