C.-C. Lee

Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice

This study shows that TYK2 inhibitors reduce islet inflammation and delay type 1 diabetes onset in mice by modulating immune and endocrine responses.

Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry

This study shows that HDI sodium butyrate improves β cell function and calcium signaling in diabetes by restoring STIM1 and SOCE, and inhibiting GSK-3 through AKT.

Stromal Interaction Molecule 1 Maintains β Cell Identity and Function in Female Mice through Preservation of G Protein-Coupled Estrogen Receptor 1 Signaling

This study shows that STIM1 maintains β cell identity and function in female mice by preserving GPER1 signaling, which is disrupted by high-fat diet.

SERCA2 regulates proinsulin processing and processing enzyme maturation in the pancreatic β cell

This study identifies SERCA2 as a regulator of proinsulin processing and processing enzyme maturation in pancreatic β cells, linking ER Ca2+ levels to impaired glucose tolerance in diabetes.

Omicron-specific mRNA vaccine induced potent neutralizing antibody against Omicron but not other SARS-CoV-2 variants

This study evaluates Omicron-specific mRNA vaccines and finds they induce strong neutralizing antibodies against Omicron but not other variants, while bivalent vaccines show broader neutralizing activity.