Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain
A. Sakai, T. Yasui, M. Watanave, R. Tatsumi, Y. Yamamoto, W. Takano, Y. Tani, I. Okamura, H. Hirai, S. Takeda, S. Takeda
This study identifies novel GPR85 inverse-agonists with IC50 values around 1 µM and shows they modulate potassium channel opening in cerebellar Purkinje cells.
bioRxiv · Sep 18, 2021Pharmacology & Toxicology