Pharmacology & ToxicologybioRxiv
Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain
A. Sakai, T. Yasui, M. Watanave…·S. Takeda
This study identifies novel GPR85 inverse-agonists with IC50 values around 1 µM and shows they modulate potassium channel opening in cerebellar Purkinje cells.
DOI 10.1111/gtc.12931