Y. Yamamoto

This study develops bispecific antibodies that restore effectiveness against SARS-CoV-2 variants resistant to existing antibodies by combining non-neutralizing antibodies targeting different epitopes.

The paper investigates the virological features of the SARS-CoV-2 EG.5.1 variant, finding its fitness and antiviral sensitivity comparable to XBB.1.5, with structural differences in spike proteins.

This study identifies XBB as a SARS-CoV-2 variant resulting from recombination of BA.2 subvariants, showing increased resistance to neutralizing antibodies and enhanced fusogenicity compared to BA.2.75.

The paper investigates convergent evolution in SARS-CoV-2 Omicron subvariants, identifying five critical spike protein substitutions in BQ.1.1 that enhance viral fitness and antibody resistance.

This study compares the pathogenicity of SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.5, finding BA.5 is more fusogenic and induces stronger inflammation than earlier variants.

This study investigates the virological characteristics of SARS-CoV-2 Omicron BA.2.75, finding it has higher transmissibility and pathogenicity compared to BA.2 and BA.5, but similar sensitivity to antiviral drugs.

This study analyzes the virological characteristics of SARS-CoV-2 Omicron variants BA.2.12.1, BA.4, and BA.5, finding they have higher reproduction numbers, reduced neutralization by prior immunity, increased replication in lung cells, and greater pathogenicity in hamsters compared to BA.2.

The paper develops a gradient-based optimization method to recover ionic current conductances from action potentials of hiPSC-CMs, showing convergence to the original parameter values.

This study identifies miR-891b and PSAT1 as regulators of EV secretion and cancer progression through the serine-ceramide pathway.

This study evaluates the anti-inflammatory effects of five CpG-ODN in chick macrophages, finding that CpG-C2395 significantly reduces inflammation-related gene expression.

This study shows that LAG3 deficiency in mice leads to rapid rejection of kidney allografts via antibody-mediated rejection, highlighting LAG3's role in regulating anti-donor humoral immunity.

This study uses scMeta-analysis to integrate public scRNA-seq data from smoking lungs, revealing expressional diversity and aging-related gene expression differences linked to smoking-induced carcinogenesis.

This study infers the demographic history of Japanese eel using genomic data, revealing population bottlenecks and growth periods linked to environmental changes.

The paper identifies two cancer stem cell-like populations in TNBC xenografts using transcriptomic analysis and confirms their presence in patient data, suggesting potential as biomarkers and implications for drug resistance.

This study identifies novel GPR85 inverse-agonists with IC50 values around 1 µM and shows they modulate potassium channel opening in cerebellar Purkinje cells.

This paper develops a hamster model of SARS-CoV-2 infection using a pseudotyped virus, showing dose-dependent luminescence in the lungs.

This study identifies NIK upregulation in breast cancer due to translational dysregulation, which promotes tumorigenicity by activating the non-canonical NF-κB pathway.

The paper introduces a method to visualize two endogenous chromatin loci in living cells using synthetic zinc-finger proteins and frankenbodies, revealing their dynamic association and separation upon cohesin disruption.

The paper investigates the reproductive biology of Letharia fungi, finding haploidy in some specimens and triploid-like features in others, suggesting hybridization and asexual reproduction in certain regions.

This study evaluates SARS-CoV-2 neutralizing antibodies using a pseudotyped virus assay and compares results with immunofluorescence assay findings.

The paper investigates the role of the CX3CL1-CX3CR1 axis in skin carcinogenesis, finding that it promotes tumor-associated macrophage recruitment and function, contributing to cancer progression.

This study identifies miR-26a as a regulator of extracellular vesicle secretion in prostate cancer cells by targeting SHC4, PFDN4, and CHORDC1, which inhibits tumor progression.