One gene - two proteins: The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration.
F. Petragnano, I. Fasciani, Z. Wang, R. Edwards, N. Telugu, I. Pietrantoni, U. Zabel, H. Zauber, M. Grieben, M. E. Terzenidou, J. Di Gregorio, C. Pellegrini, S. Santini, A. R. Taddei, B. Poehl, , R. Maggio
The paper shows that the C-terminal fragment of the M2 muscarinic receptor localizes to mitochondria and regulates cell respiration, independent of its canonical GPCR function.
bioRxiv · Apr 13, 2021Cell Biology