A. B. Tobin

Phosphorylation bar-coding of Free Fatty Acid receptor 2 is generated in a tissue-specific manner

The paper demonstrates tissue-specific phosphorylation patterns of FFA2 in response to the same agonist in different tissues using transgenic mice and phospho-specific antibodies.

Phosphorylation of the M1 muscarinic acetylcholine receptor mediates protection in neurodegenerative disease

This study shows that phosphorylation and arrestin-dependent signaling of the M1 muscarinic receptor provides neuroprotection in prion disease, suggesting potential for developing safer therapies for neurodegenerative diseases.

One gene - two proteins: The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration.

The paper shows that the C-terminal fragment of the M2 muscarinic receptor localizes to mitochondria and regulates cell respiration, independent of its canonical GPCR function.

Pathophysiological regulation of lung function by the free fatty acid receptor FFA4

This study shows that activating FFA4 reduces airway resistance in mouse models of inflammation and human lung tissue, suggesting it could be a therapeutic target for asthma and COPD.

Chemogenetic analysis of how receptors for short chain fatty acids regulate the gut-brain axis

This study identifies a specific agonist for a modified FFA2 receptor and demonstrates distinct roles of FFA2 and FFA3 in gut-brain communication using genetically engineered mice.

Crystal structure of the M5 muscarinic acetylcholine receptor

The paper reports the crystal structure of the human M5 muscarinic acetylcholine receptor bound to tiotropium, revealing structural differences that inform ligand selectivity design.