R. Edwards

A Fungal Spore Calendar for England: Analysis of 13 years of Daily Concentrations at Leicester, UK

The paper develops a fungal spore calendar for Leicester, UK, based on 13 years of daily spore concentration data, identifying seasonal trends and meteorological influences.

Structural insights into γH2Ax containing nucleosomes

The paper characterizes the interaction between MDC1 BRCT domains and γH2AX nucleosomes using cryo-EM, revealing structural insights into nucleosome stacking and its disruption by BRCT binding.

Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaques

This study shows that vaccinating macaques with a CD4bs-targeting immunogen elicits neutralizing bnAb precursors with structural features of CD4-mimicking antibodies.

Allosteric Regulation of a Synaptic Vesicle Glutamate Transporter

The paper determines the structure of VGLUT2 with a glutamate analog bound, revealing mechanisms of substrate recognition, electrostatic interactions, and palmitoylation's role in transporter retrieval.

Pre-neoplastic stromal cells drive BRCA1-mediated breast tumorigenesis

The paper shows pre-neoplastic stromal cells promote BRCA1-driven breast cancer by inducing epithelial proliferation and altering differentiation.

A Thioredoxin reductive mechanism balances the oxidative protein import pathway in the intermembrane space of mitochondria

This study identifies the cytosolic thioredoxin system's role in balancing mitochondrial oxidative folding via its localization in the intermembrane space and its regulation of Mia40 redox state.

One gene - two proteins: The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration.

The paper shows that the C-terminal fragment of the M2 muscarinic receptor localizes to mitochondria and regulates cell respiration, independent of its canonical GPCR function.

Dynamics of infection in a novel group of promiscuous phages and hosts of multiple bacterial genera retrieved from river communities

The paper identifies and characterizes promiscuous phages capable of infecting multiple bacterial genera in river communities, revealing dynamic infection dynamics and adaptation patterns.

A Distinct Contractile Injection System Found in a Majority of Adult Human Microbiomes

The paper identifies a widespread Contractile Injection System in adult human microbiomes, suggesting it mediates interactions between Bacteroidales bacteria and the host or microbiome.

Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

This study identifies a critical role for W571 in HIV-1 Env allostery by showing mutations disrupting CD4-induced rearrangements and rendering Env insensitive to CD4 binding.

Genetic, morphometric, and molecular analyses of interspecies differences in head shape and hybrid developmental defects in the wasp genus Nasonia

The paper investigates gene interactions affecting head shape and developmental defects in Nasonia wasp hybrids, showing codominance of shape alleles and recessive defects, and identifies doublesex as necessary but not sufficient for male head shape differences.

Global phylogeography and ancient evolution of the widespread human gut virus crAssphage

This study investigates the origin, evolution, and epidemiology of crAssphage, a widespread human gut virus, using global DNA sequences showing local phylogeographic clustering and ancient primate associations.

MiR-195 regulates mitochondrial function by targeting mitofusin-2 in breast cancer cells

This study shows miR-195 regulates mitochondrial function by targeting mitofusin-2, leading to mitochondrial fission and altered oxidative stress in breast cancer cells.