Z. Wang

Marker-specific pixel attribution for single-cell protein quantification with PixAQ

PixAQ improves single-cell protein quantification in imaging mass cytometry by assigning pixel signals to specific markers using spatial and intensity models.

Discovery of A Multi-Class Antibiotic Potentiator Against Resistant Klebsiella pneumoniae

This study identifies a tetrahydrocarbazole compound that potentiates multiple antibiotics against multidrug-resistant Klebsiella pneumoniae.

First Metagenome-Assembled Genomes from the Historic Morrow Plots Reveal Management-Associated Dominance of Archaeal Ammonia Oxidizers

The paper presents metagenome-assembled genomes from the Morrow Plots, revealing management-associated dominance of archaeal ammonia oxidizers in agricultural soils.

Performance Characteristics of Zeno Trap Scanning DIA for Sensitive and Quantitative Proteomics at High Throughput

The paper evaluates ZT Scan DIA, a proteomics method combining scanning DIA with ion trapping, showing improved precursor and protein identification, quantification, and bias reduction in multi-species mixtures.

Brain Charts for the Rhesus Macaque Lifespan

This study creates normative brain growth charts for rhesus macaques across their lifespan using MRI data, revealing developmental milestones and cross-species comparisons with humans.

Exploring the Mechanism of Gentiana in Treating Pancreatic Cancer Based on Network Pharmacology and Molecular Docking Techniques

This study identifies 72 common genes and 15 signaling pathways involved in Gentiana's potential treatment of pancreatic cancer using network pharmacology and molecular docking.

Modeling plant-microbe interactions with species distribution models

This paper presents a framework for modeling plant-associated microbial distribution using process-oriented approaches and discusses challenges in data collection and interpretation.

Hotwiring integrin endocytosis acutely modulates cell interactions

This study uses hot-wired endocytosis to acutely downregulate 5{beta}1 integrins, showing reduced cell area, fibronectin uptake, and slower tumor spheroid compaction.

Digital pathology assessment of kidney glomerular filtration barrier ultrastructure in an animal model of podocytopathy

This paper develops a deep learning method to automate measurement of glomerular basement membrane and podocyte foot process widths in TEM images of podocytopathy mouse models, showing comparable accuracy to manual methods.

Fitness advantage of sequential metabolic strategies emerges from community interactions in strongly fluctuating environments

The paper compares fitness of microbial metabolic strategies in fluctuating environments, finding sequential utilizers gain an advantage in diverse communities.

Poxvirus A52 is a host range factor for modified vaccinia virus Ankara (MVA) and promotes viral replication by disturbing the formation of autolysosomes

This study identifies poxvirus protein A52 as a host range factor that disrupts autolysosome formation to promote viral replication in MVA.

Adaptation-induced oscillatory phototaxis and emergence of ordered density bands in the microswimmer Chlamydomonas reinhardtii

The paper studies oscillatory phototaxis in Chlamydomonas reinhardtii, showing how adaptation leads to collective density band formation under constant light.

Marginated neutrophils in the lungs effectively compete for nanoparticles targeted to the endothelium, serving as a part of the reticuloendothelial system

The paper shows that lung marginated neutrophils effectively uptake endothelial-targeted nanoparticles, suggesting they are part of the reticuloendothelial system.

LiveLattice: Real-time visualization of tilted light-sheet microscopy data using a memory-efficient transformation algorithm

This paper introduces WH-Transform, a GPU-accelerated algorithm for real-time preprocessing of tilted light-sheet microscopy data, enabling fast visualization and analysis of large datasets.

The main duct of von Ebner's glands is a source of Sox10+ taste bud progenitors and susceptible to pathogen infections

Compositional Shifts and Co-occurrence Patterns of Topsoil Bacteria and Micro-Eukaryotes Across a Permafrost Thaw Gradient in Alpine Meadows of the Qilian Mountains, China

This study examines how permafrost thaw affects bacterial and micro-eukaryotic communities in alpine meadows, finding distinct responses in diversity and co-occurrence patterns.

Epigenetic upregulation of carotid body angiotensin signaling increases blood pressure

This study shows perinatal nicotine exposure increases DNA methylation in the angiotensin II type 1 receptor gene in carotid bodies, enhancing angiotensin signaling and leading to hypertension.

Epithelial NSD2 maintains FMOs-mediated taurine biosynthesis to prevent intestinal barrier disruption

The paper shows NSD2 maintains taurine biosynthesis via FMOs in intestinal epithelial cells, preventing barrier disruption in IBD.

Identification of Candidate Diagnostic gene CDC25C for Trametinib-induced Cardiotoxicity by Integrating Bioinformatics and Machine Learning

Bispecific antibodies with broad neutralization potency against SARS-CoV-2 variants of concern

The paper designs bispecific antibodies that retain neutralization activity against multiple SARS-CoV-2 variants, including Omicron subvariants.

Recombinant expression, purification, and antifungal activity of the novel antimicrobial peptide TaW662

This study identifies and characterizes TaW662, an antifungal peptide from wheat, showing inhibition of Blumeria graminis f. sp. tritici growth and potential as a fungicide.

Functional and antigenic landscape of the Nipah virus receptor binding protein

This study uses deep mutational scanning to analyze how mutations in the Nipah virus receptor-binding protein affect function, receptor binding, and antibody escape, revealing constrained regions and limited antigenic variation in natural strains.

Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus

This study reports the 3.2 Å resolution structure of the Pseudomonas aeruginosa PAO1 Type IV pilus using cryo-EM, revealing its architecture and potential functional roles.

Cross-subject brain entropy mapping

This paper introduces a method to map regional similarity between resting state fMRI activities across individuals using cross-entropy, applied to the Human Connectome Project Youth data.

Kilohertz volumetric imaging of in-vivo dynamics using squeezed light field microscopy

This paper introduces squeezed light field microscopy (SLIM), a method for high-speed 3D volumetric imaging, and demonstrates its application in tracking blood cell motion and neural activity in vivo.

Tuning non-linear mechanics in collagen hydrogels modulates three dimensional cellular morphotypes

This study shows that altering the non-linear elasticity of collagen hydrogels affects cell morphology, migration, and matrix deformation through mechanical interactions with a second polymer component.

Microbial Response to Natural Disturbances: Rare Biosphere often plays a role

The paper defines rare biosphere and generalists using metagenomic and macroecological metrics, showing their roles in microbial resilience to disturbances like tropical cyclones and warming.

Buzz-world: Global patterns and drivers of buzzing bees and poricidal plants

This study examines global patterns and drivers of buzzing bee distribution, finding that poricidal plant richness significantly influences buzzing bee biodiversity.

Glioma-associated fibroblasts promote glioblastoma resistance to temozolomide through CCL2-CCR2 paracrine signaling

This paper shows that glioma-associated fibroblasts enhance glioblastoma resistance to temozolomide by secreting CCL2, which activates the ERK1/2 pathway in cancer cells.

Past, present, and future spatial distributions of deep-sea coral and sponge microbiomes revealed by predictive models

This paper predicts the spatio-temporal distribution of deep-sea coral and sponge microbiomes using environmental, host, and microbiome data across 214 years.