Inhibition of inositol-requiring enzyme 1 RNase activity protects pancreatic beta cell and improves diabetic condition in insulin mutation-induced diabetes
O. Herlea-Pana, V. Eeda, R. Undi, I. Rus, H.-Y. Lim, W. Wang
This study shows that inhibiting IRE1 RNase activity protects beta cells and improves diabetes in Akita mice with insulin mutation-induced diabetes.
bioRxiv · Aug 30, 2020 · PreprintPharmacology & Toxicology