H.-Y. Lim

Targeting IRE1alpha improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice

This study shows that inhibiting IRE1 improves insulin sensitivity, thermogenesis, and reduces metabolically active adipose tissue macrophages in obese mice.

Designing Efficient Enzymes: Eight Predicted Mutations Convert a Hydroxynitrile Lyase into an Efficient Esterase

The paper identifies eight mutations that convert a hydroxynitrile lyase into an efficient esterase by correcting structural differences using shortest path maps.

Inhibition of inositol-requiring enzyme 1 RNase activity protects pancreatic beta cell and improves diabetic condition in insulin mutation-induced diabetes

This study shows that inhibiting IRE1 RNase activity protects beta cells and improves diabetes in Akita mice with insulin mutation-induced diabetes.